Objectives: To conduct a systematic review and meta-analysis regarding the efficacy and safety of inhaled corticosteroids for COPD exacerbations.Study Selection: Randomized double-blind clinical trial, inhaled corticosteroids and child growth.Data Extraction and Synthesis: We performed a systematic review, meta-analysis and meta-analysis in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement of the Cochrane Collaboration, nebulized steroids list. We searched the available databases of controlled trials of inhaled corticosteroids in COPD using key words related to COPD and COPD exacerbations for relevant publications (September 2006), list of nebulized steroids. Data extraction was performed independently through both authors and a third author. Additional information was extracted according to the available data.Data Synthesis: We searched the systematic review and meta-analysis databases identified and searched by using the full name of the article, the name of the study and all relevant studies, corticosteroid respiratory drugs. Additionally, we conducted a search of selected online literature to assess the literature. We also performed a new search using key words for CVD (cholesterol, triglycerides, blood pressure, diabetes, hypercholesterolemia, hyperlipoproteins, hyperinsulinemia, hypertriglyceridemia, antihypertensive drug, calcium, phosphate, vitamins, minerals, antihypertension drugs, antihypertensive drugs, calcium) and COPD (acute lung infection, asthma, bronchitis, COPD, acute pulmonary embolism, pneumonia), inhaled corticosteroids side effects. The search term 'intubation, CO' or 'intubation, CT/PA' was also used in our search. Thereafter, articles were extracted for comparative efficacy and safety data.Main Outcomes and Measures: All studies were evaluated to determine the effectiveness and safety of the use of inhaled corticosteroids as adjunct therapy in the treatment of COPD for exacerbations of asthma.Results: We identified 13 RCTs which included patients who had experienced exacerbations of asthma, inhaled uses corticosteroids. Four studies (8%) were randomized. Out of the 11 studies included, there were 4,971 patients in the randomization group and 1,898 patients in the control group, inhaled corticosteroids uses. There were significant improvements in lung function in the treatment group (p < , inhaled corticosteroids side effects.001) but no significant changes in cardiac function in the control group (p > , inhaled corticosteroids side effects.05), inhaled corticosteroids side effects. In 12 of 13 studies (94%), the adverse events were either mild (p < .001) or moderate (p < .001) compared to placebo. In six of the studies (32%), there were no adverse events.
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